Following where the previous film left off, Alice (Milla Jovovich) and the others on the Umbrella Corporation freighter Arcadia face an attack by a fleet of airships led by Alice's former ally Jill Valentine (Sienna Guillory), who has been brainwashed by Umbrella through a red scarab device attached to her chest. When Alice causes an airship to crash into the ship, she is knocked unconscious into the water.
Switching over into what seems to be an alternate reality, Alice finds herself living as a suburban housewife with her husband Todd (Oded Fehr) — a doppelganger of Carlos Olivera — and deaf daughter Becky (Aryana Engineer). However, this idyllic life is disrupted when zombies attack and kill Todd. Alice and Becky escape to the streets and are rescued by Rain Ocampo (Michelle Rodriguez), who lets them ride in her car. As the three escape, they are hit by a truck, knocking Rain unconscious while Alice and Becky escape. Alice runs and is attacked by a zombified Todd.
The apparent dream ends when the the real Alice awakens in an Umbrella base, having been captured at the Arcadia. Jill interrogates Alice, who unsuccessfully pleads with her to remember her true identity. During an unexpected power failure, Alice escapes from her cell. After battling a horde of zombies, Alice encounters Ada Wong (Li Bingbing), an associate of Albert Wesker (Shawn Roberts). Ada explains that she and Wesker no longer work for Umbrella. Wesker appears and, seeming to have redeemed himself, reveals that he plans to aid Alice's escape and battle the base's supercomputer Red Queen (Megan Charpentier and Ave Merson-O'Brian), in order to save what's left of mankind. Ada also reveals that the base is underwater and serves as a testing ground for experiments. Additionally, Wesker has organized a team of freelance operatives to infiltrate the base and help Alice and Ada escape, including Leon S. Kennedy (Johann Urb), Barry Burton (Kevin Durand), and Luther West (Boris Kodjoe).
Leon's team plants explosives near the entrance of the base, which will detonate in two hours and trap anybody still inside. The group plans to meet with Alice and Ada in a simulated Raccoon City suburbia, identical to the one in Alice's flashback. As Alice and Ada walk through a simulation of New York City, they defeat two Axemen. Leon and his team enter a Moscow simulation, but are cut off by armed Las Plagas zombies. Alice and Ada manage to enter the suburban simulation where they were supposed to meet up with Leon and his team. In the arena the two find Becky, as well as Jill and her mercenaries, consisting of clones of Alice's deceased allies: Rain, Carlos and James "One" Shade (Colin Salmon). A shoot-out occurs, resulting in Ada being captured and Alice and Becky escaping.
Alice and Becky run into the "good" Rain (the one encountered in Alice's dream), and head to Moscow, where they meet up with Leon's team. The group escapes the intelligent zombies, and reach an elevator that leads them to submarines that could help them escape, although it shuts off. An enormous licker appears, with it capturing Becky and killing "good" Rain. The group pursues the licker, where they encounter Jill's group; another battle ensues, in which Barry is killed. Alice manages to rescue Becky. During their escape from the licker they arrive at a cloning facility where Alice and Becky see multiple copies of themseves. Realizing this Becky pleads and asks Alice to tell her the truth, at which Alice declares that she is now her mother. The licker returns, forcing Alice set off the explosives she got for the pod where she rescued Becky from, killing off the licker and destroying the cloning facility. They rejoin Leon and Luther as the detonation occurs. The explosion results in the flooding of the facility and the deaths of One and Carlos.
The group reaches the surface; however, they are met by a submarine, from which Jill, the evil Rain, and a captured Ada emerge. With new orders from the Red Queen to kill Alice, Jill battles Alice while Rain, injecting herself with the Las Plagas parasite that gives her strength and apparent invincibility, knocks out Ada and fights Leon and Luther, with Luther being killed in the process. Alice manages to remove and destroy the scarab device from Jill, returning her back to normal. Alice joins Leon in fighting Rain; she notices there are zombies from the facility swimming up to the ice. She shoots the ice where Rain is standing, and she falls in the water, leaving her fate to the zombies. Alice, Ada, Becky, Leon, and Jill (who is no longer being controlled by the Red Queen) travel to Wesker's base: the heavily barricaded and guarded White House. Wesker injects her with the T-virus, returning her former superhuman powers in order to enact his plan, then tells her that she is responsible for saving the remaining humans from extinction once and for all. After they walk onto the top of The White House, the scene zooms out to reveal the landscape around them, showing enormous hordes of zombies, flying creatures and other monsters.
mp: dunia semakin nggilani....apa mrk sadar zombi ini adl representasi dr org2 nyata di dunia yg saling makan sesamanya
